Eleven new Ebola cases with six deaths were recorded on Thursday in Boke prefecture, some 100km from the capital Conakry, local sources said.
In Conakry, the authorities confirmed that one person had died recently from the virus.
The home confinement began on Tuesday and aims to limit the movement of population in and out of affected areas.
Ebola-hit Sierra Leone also quarantined three doctors and 28 nurses after a woman who had recently given birth tested positive for the deadly virus last Saturday.
The Ebola epidemic, believed to the worst on record, has killed more than 11,000 people in Guinea, Sierra Leone and Liberia since last year.
Liberia was announced Ebola-free in May, but Sierra Leone and Guinea are still in flight with the virus.
By Ruchi Singh