Amorepacific has confirmed the mechanism of autophagy activation through its proprietary material, red flavonoid, and its effects on improving the skin barrier in aging skin. Researchers examined the mechanism in cell and artificial skin models and verified changes in moisture and skin barrier-related indicators in human trials.
On November 11, Amorepacific announced that the related research findings were published online last month in the international dermatology journal, Experimental Dermatology. This study follows a joint research project with KAIST that identified the potential for skin rejuvenation using red flavonoid as a key ingredient.
Autophagy is the process by which cells break down and recycle damaged components. As people age, this function declines, leading to the accumulation of damaged components and a thinning epidermis, which can impair skin barrier function.
The research team found that excessive activation of the protein PDK1, which is involved in cell growth and inflammatory responses, contributes to the decline of autophagy function in aging skin. The main component of red flavonoid, extracted from camellia seeds, was shown to regulate PDK1 and activate the diminished autophagy function.
The team also conducted a randomized, double-blind, placebo-controlled human trial involving women over 60 for four weeks. After using the formulation containing red flavonoid, the transepidermal water loss decreased, while skin moisture levels and ceramide content in the stratum corneum increased. Improvements were also observed in epidermal thickness and skin barrier-related indicators.
Amorepacific is currently applying this technology to its key functional products under the Sulwhasoo, Laneige, and AP Beauty brands.
Seo Byeong-hwi, Chief Technology Officer of Amorepacific's R&I Center, stated, "This research advances the scientific basis for addressing the decline of autophagy in aging skin and improving skin barrier function using our proprietary anti-aging material. We will continue to research the fundamental causes of skin aging."
Meanwhile, Amorepacific Group plans to expand its global business focusing on dermabeauty, clinical skincare, and hair care. It aims to enhance the international market presence of various brands based on its research and development (R&D) and digital competitiveness.
* This article has been translated by AI.
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